ERTAPENEM PACKAGE INSERT PDF

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For Package Inserts, please click on the NDC#. Presentation(s):1g; Reference Listed Drug:Invanz®; Therapeutic Class: Antibacterial, carbapenem type. INVANZ 1 g powder for concentrate for solution for infusion. 2. . This medicinal product contains approximately mEq (approximately mg) of sodium per g dose which should Package Leaflet: information for the user. INVANZ 1 . Product Availability · Contact Us · Make An Inquiry. () Product Summary. Ertapenem Sodium Injection. Therapeutic Class: Carbapenem Antibiotic.

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The exact mechanism of this interaction is not known, however, based on in vitro and animal data, inhibition of valproic acid glucuronide hydrolysis is a paackage mechanism. Theoretically, efflux activity plus loss of membrane permeability is less likely to happen in vivo than AmpC beta-lactamase expression and loss of membrane permeability.

Ertapenem is structurally similar to the penicillins and cephalosporins and these patients may be more susceptible to hypersensitivity reactions.

Ertapenem for Injection

In animal studies evaluating doses 1. If ertapenem is given within 6 hours of hemodialysis, a supplementary dose of mg is recommended following the hemodialysis session.

Case studies have reported ertapenem causing decreases in valproic acid pavkage divalproex serum concentrations when ertapenem was added to their regimen; discontinuation of ertapenem resulted in increased valproic acid concentrations.

Patients who have experienced anaphylactic reactions to penicillins or cephalosporins should not receive ertapenem. The MICs are defined for beta-hemolytic group Streptoccoccus sp. Carbapenems can reduce serum concentrations of valproic acid to ertapenek levels when the two drugs are administered together. Send the page ” ” to a friend, relative, colleague or yourself.

Antibiotics are non-selective and may result in the eradication of beneficial microorganisms while promoting the emergence of undesired ones, causing secondary infections such ertapeenem oral thrush, colitis, or vaginitis. Monitor patients for signs and symptoms of bleeding. Shake well to dissolve. It exhibits non-linear pharmacokinetics due to a high level of concentration-dependent plasma protein binding to albumin.

These authors concluded that because females most at risk for OC failure or noncompliance may not be easily identified and the true incidence of such events may be under-reported, and given the serious consequence of unwanted pregnancy, that recommending an additional method of contraception during short-term antibiotic use may be justified.

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Your Name Your name is required. Use with a needless IV system is not recommended.

Ertapenem for Injection — AuroMedics Pharma LLC

Ertapenem is stable against hydrolysis by a variety of beta-lactamases, including penicillinases, cephalosporinases and extended-spectrum beta-lactamases. Retapenem, diarrhea, GI disease, inflammatory bowel disease, pseudomembranous colitis, ulcerative colitis.

Carbapenem hypersensitivity, cephalosporin hypersensitivity, penicillin hypersensitivity. In the colon, overgrowth of Clostridia may exist when normal flora is altered subsequent to antibacterial administration.

Surgical intervention packag the primary therapeutic intervention. Complete the infusion within 6 hours of reconstitution. If focal tremor or myoclonic seizures occur, patients should be evaluated neurologically.

Visually inspect parenteral products for particulate matter and discoloration prior to administration whenever solution and container permit. For the treatment of complicated intraabdominal infections. In setting of a cat or dog bite, preemptive antimicrobial therapy is recommended for 3 to 5 days for patients who are immunocompromised, asplenic, have advanced liver disease, have edema of the bite area, have moderate to severe injuries, particularly of the hand or face, or have penetrating injuries to the periosteum or joint capsule.

Practitioners should be aware that antibiotic-associated colitis has been observed to occur over two months or more following discontinuation of systemic antibiotic therapy; a careful medical history should be taken. Consider transitioning to an appropriate oral therapy after at least 3 days of parenteral therapy, once clinical improvement has been demonstrated.

Any antibiotic may cause diarrhea, nausea, vomiting, anorexia, and hypersensitivity reactions. One retrospective study reviewed the literature to determine the effects of oral antibiotics on the pharmacokinetics of contraceptive estrogens and progestins, and also examined clinical studies in which the incidence of pregnancy with OCs and antibiotics was reported.

Agitate well to form a solution. No data are available regarding use in pediatric patients with renal pwckage. Ertapenem should be prescribed with caution to patients with inflammatory bowel disease such as ulcerative colitis or other GI disease.

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Almost all antibacterial agents have been associated with pseudomembranous colitis antibiotic-associated colitis which may range in severity from mild to life-threatening. For the treatment of complicated urinary tract infection UTI pyelonephritisincluding cases with concurrent bacteremia.

Related Drug Information Drug Summary. Peak plasma concentrations following a 1 g dose are achieved in roughly 2.

Ertapenem Sodium Injection – Par Sterile Products – Products

Major Concomitant use of carbapenems doripenem, ertapenem, imipenem, meropenem and valproic acid is not recommended. The percentage of time required for both bacteriostatic and maximal bactericidal activity is different for the various classes of beta-lactams. In some instances, this effect is used therapeutically to increase availability of the antimicrobial agent. It is eliminated via the kidney with a prolonged half-life of roughly 4. IV or IM broad-spectrum carbapenem antibiotic stable against beta-lactamases Used to treat UTI, skin, pelvic, intraabdominal infections and community-acquired pneumonia; used for colorectal surgical prophylaxis Once-daily dosing may be advantageous, but no P.

Dilute the appropriate volume of the reconstituted solution based on body weight in 0. In moderate to severe cases, fluids and electrolytes, protein supplementation, and treatment with an antibacterial effective against Clostridium difficile may be warranted.

For surgical infection prophylaxis for elective colorectal surgery. In milder cases, the colitis may respond to discontinuation of the offending agent. The diluted solution may be refrigerated for up to 24 hours 5 degrees C and used within 4 hours after removal from refrigeration.

It was concluded that the antibiotics ampicillin, ciprofloxacin, clarithromycin, doxycycline, metronidazole, ofloxacin, roxithromycin, temafloxacin, and tetracycline did not alter plasma concentrations of OCs. Anticonvulsive therapy should be continued in patients with a known seizure disorder. PBP-1 is responsible for formation of the cell wall; PBP-2 is responsible for maintaining the rod-like shape; and PBP-3 is responsible for bacterial septum formation.