Fibrolamellar hepatocellular carcinoma (FHCC) is a rare form of hepatocellular carcinoma (HCC) that typically affects young adults and is characterized, under. Although fibrolamellar carcinoma (FLC) has conventionally been considered to be a histologic variant of hepatocellular carcinoma (HCC). Summary. An Orphanet summary for this disease is currently under development. However, other data related to the disease are accessible.

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Fibrolamellar hepatocellular carcinoma is a distinct histological variant of hepatocellular carcinoma characterised on microscopy by laminated fibrous layers between the tumor cells.

Imaging of fibrolamellar hepatocellular carcinoma. The tumor cells are arranged in cords that are separated by sheetlike fibrous bands arranged in a parallel or lamellar distribution 4: We present the case of a year-old patient with metastatic FL-HCC to the pancreas 30 years after diagnosis and 26 years since his last resected liver recurrence.

They may also fibrolamepar a palpable liver mass.

The American journal of gastroenterology ; Hepayocelular Read Edit View history. Hepatocellular carcinoma Hepatocellular carcinoma. Discussion Fibrolamellar hepatocellular carcinoma usually occurs among young patients having distinctive clinical, histological and prognostic features Only comments seeking to improve the quality and accuracy of information on the Orphanet website are accepted. In FHCC, plasma neurotensin and serum vitamin Cacinoma binding globulin are commonly increased and are useful in monitoring the disease and detecting recurrence.

All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License. Cancer ; 46 2: Docente Universidad de Antioquia.

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It is associated with elevated neurotensin levels. Outcome of patients with fibrolamellar hepatocellular carcinoma. He had done well since his liver transplantation until Augustwhen a left lung nodule 3 cm in size was noted fibrokamelar a PET CT, in addition to a 2-cm borderline hypermetabolic lesion in the tail of the pancreas. Retrieved from ” https: In our patient, MRI showed, in addition to the nodule in the left lower lobe, a 2.

Calcification in focal nodular hyperplasia: The patient was sent to the oncologist and is under oxaliplatin, folinate calcium and 5-fluorouracil.

Orphanet: Carcinoma hepatocelular fibrolamelar

This disease was first described by Edmondson in a year-old female fobrolamelar no underlying liver disease. Adenocarcinoma Pancreatic ductal carcinoma cystic neoplasms: Loading Stack – 0 images remaining.

The patient was then referred to surgery for resection of his lung nodule and pancreatic tail mass.

These include the presence of sheets of large polygonal or spindle-shaped tumor darcinoma with abundant granular eosinophilic cytoplasm, prominent nuclei, and paucicellular fibrous stroma arranged in thin parallel lamellae around tumor cells. Technetiumm sulfur colloid scans taken up by Kupffer cells are useful as these tumours will not accumulate the agent, whereas focal nodular hyperplasia does.

Instead, it has been associated with elevations in neurotensin levels [ 5 ]. Hepatocelula the more common HCC, patients most often do not have coexistent liver disease such as cirrhosis.

However, other data related to the disease are accessible from the Additional Information menu located at the bottom of this page. How to cite this article.

A year-old woman who presented fever and epigastric discomfort was palpable a painful hepatomegaly at the expense of the left hepatic lobe LHL no other findings in the rest of the examination.


Differential diagnosis of tumors and tumor-like lesions of liver in infancy and childhood.

Metastatic Fibrolamellar Hepatocellular Carcinoma to the Pancreas

These tumours are well-differentiated and well-circumscribed, with a dense fibrotic background 2. Radiol Clin North Am ; The liver was normal.

GCR ; 6 1: It is important as it has different demographics and risk factors compared to ‘standard’ hepatocellular carcinomas. Occasionally it may be T2 hyperintense mimicking FNH 1.

The central scar, hepatkcelular present, is usually hypointense on all sequences. The conclusions reinforce the importance of radiological imaging for the detection and characterization of hepatic focal neoplasms.

Fibrolamellar hepatocellular carcinoma: a case report

Advances in anatomic pathology ; 14 3: Characteristics of fibrolamellar hepatocellular carcinoma. Serous microcystic adenoma Intraductal papillary mucinous neoplasm Mucinous cystic neoplasm Solid pseudopapillary neoplasm Pancreatoblastoma. For all other comments, please send your remarks via contact us.

Diseases of liver Pediatric cancers Digestive system neoplasia Rare cancers. Epidemiology of fibrolamellar hepatocellular carcinoma in the USA, — The patient was then referred for evaluation and diagnosis of the pancreatic mass by endoscopic ultrasound-guided fine-needle aspiration EUS-FNA. Radiology ; 1: A thoraco-abdominal computed tomography had been made in his reference hospital finding multiple nodular lesions in hepatocepular lungs and a hepatic mass 14 x 10 cm.

Author information Copyright and License information Disclaimer. Hepatocellular carcinomas in cirrhotic and noncirrhotic human livers share angiogenic characteristics.